mRNA structure determines modification by pseudouridine synthase 1
نویسندگان
چکیده
منابع مشابه
Correction: Steroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model
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متن کاملSteroid Receptor RNA Activator (SRA) Modification by the Human Pseudouridine Synthase 1 (hPus1p): RNA Binding, Activity, and Atomic Model
The most abundant of the modified nucleosides, and once considered as the "fifth" nucleotide in RNA, is pseudouridine, which results from the action of pseudouridine synthases. Recently, the mammalian pseudouridine synthase 1 (hPus1p) has been reported to modulate class I and class II nuclear receptor responses through its ability to modify the Steroid receptor RNA Activator (SRA). These findin...
متن کاملSpatially controlled expression of the Drosophila pseudouridine synthase RluA-1.
Pseudouridine (Ψ) synthases function in the formation of Ψ, the most abundant of the modified RNA residues. All Ψ synthases in E. coli are classified into one of five families according to their sequences. Among them, members of the RluA Ψ synthase family catalyze certain Ψ formations in ribosomal RNA. RluA family members are required for ribosomal assembly and bacterial growth. None of the Rlu...
متن کاملCocrystal Structure of a tRNA Ψ55 Pseudouridine Synthase Nucleotide Flipping by an RNA-Modifying Enzyme
Pseudouridine (Psi) synthases catalyze the isomerization of specific uridines in cellular RNAs to pseudouridines and may function as RNA chaperones. TruB is responsible for the Psi residue present in the T loops of virtually all tRNAs. The close homolog Cbf5/dyskerin is the catalytic subunit of box H/ACA snoRNPs. These carry out the pseudouridylation of eukaryotic rRNA and snRNAs. The 1.85 A re...
متن کاملPseudouridine synthase 1: a site-specific synthase without strict sequence recognition requirements
Pseudouridine synthase 1 (Pus1p) is an unusual site-specific modification enzyme in that it can modify a number of positions in tRNAs and can recognize several other types of RNA. No consensus recognition sequence or structure has been identified for Pus1p. Human Pus1p was used to determine which structural or sequence elements of human tRNA(Ser) are necessary for pseudouridine (Ψ) formation at...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2019
ISSN: 1552-4450,1552-4469
DOI: 10.1038/s41589-019-0353-z